Could there be immune dysregulation in absence of host-adaption-related early-life pathogen exposures? (e.g survival of ‘Immune amnesia’ following measles infection as a goldilocks threshold for local immune fitness). Is this just age demographics at play or is there something else going on, maybe along the lines of increased prevalence of autoimmune pathology and e.g schizophrenia (hypothesised by some to be-at least partly- of immune etiology) found in this population as immigrant vs in originating locations. I am still intrigued by the difference in experience of the pandemic wrt to ethnicity as it plays out in migrated populations. Is anyone aware of studies along this line? In agammglobulinemia- does this point to antibodies being a double-edged sword in SARS CoV 2 infection and does this indicate that people under immuno-suppresant therapy may not always suffer severe Covid19? The long duration of infection in one case that was studied for variant emergence apart- I think that was a cancer patient rather than auto-immune though. Is there a triaging energy-wise- T cell response less costly if effective, antibodies only if infection lasts (how long?) or damages (How much/where?)ĭo self-reactive T cells and self-reactive B cells get eliminated in similar ways and would this also process have any way of feeding back/ interacting?Īdditionally, could a T cell epitope recognised in Sars CoV 2 or vaccine ‘call up’ a related pre-existing but previously not pathological auto-antibody response? vis ‘Antinuclear Autoantibodies in Health: Autoimmunity Is Not a Synonym of Autoimmune Disease’, Pashnina et al. if so, what would be the mechanism, cytokines? Questions (hopefully not too daft!): how do T cell and B cell responses interact especially with regards to memory of infection? Does a memory T cell implicate (sometimes always ever never?) a corresponding memory B cell response. There is hope for us humans given all of you’s cheerful persistance, indefatigable curiosity and sheer blo0dy-mindedness 🙂 I loved this episode! Cheerful Dante 🙂 or as Camus said “one must imagine Sisyphus happy’. Next Post ← TWiV 737: SARS-CoV-2 in NYC wastewater
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